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CAS NO:
51014-29-0
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Basic Info
CAS Number
51014-29-0
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Isocorynoxeine is a naturally occurring alkaloid primarily isolated from the stems and leaves of Uncaria species, most notably *Uncaria rhynchophylla* (Gou Teng), a herb widely utilized in traditional Chinese and Japanese medicine. Chemically classified as an indole alkaloid, it serves as a structural isomer of corynoxeine, distinguished by its unique stereochemistry which significantly influences its biological activity. The molecular formula of Isocorynoxeine is C20H24N2O3, reflecting its complex pentacyclic structure containing oxindole and quinoline moieties. While specific CAS registry numbers for this compound can vary slightly depending on the source database due to historical naming conventions, it is generally associated with the chemical identity of this specific stereoisomer found in natural extracts.
The primary therapeutic potential of Isocorynoxeine lies in its neuroprotective and antihypertensive properties. Extensive pharmacological research suggests that it acts as a calcium channel blocker, effectively relaxing vascular smooth muscles to lower blood pressure without causing significant reflex tachycardia. Furthermore, studies indicate its ability to inhibit platelet aggregation, thereby reducing the risk of thrombosis and improving cerebral blood flow. These mechanisms make it a promising candidate for the management of cerebrovascular disorders, including ischemic stroke and hypertension-related conditions. In the context of modern drug development, Isocorynoxeine is often investigated as a lead compound for creating novel agents targeting neurological protection and cardiovascular health. Its efficacy in mitigating excitotoxicity and oxidative stress in neuronal cells has garnered attention from researchers exploring treatments for neurodegenerative diseases. Beyond clinical applications, the compound holds significance in scientific research regarding the biosynthesis of indole alkaloids and the structure-activity relationships within the Uncaria genus. As interest in botanical medicines grows globally, Isocorynoxeine represents a critical bridge between traditional herbal knowledge and evidence-based pharmaceutical innovation, offering a safer alternative or adjunct therapy for chronic vascular and neurological ailments.
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