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Intermediates&Fine Chemicals

Ibandronic acid

Category:

Intermediates&Fine Chemicals

CAS NO:

114084-78-5

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

114084-78-5

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Ibandronic acid 114084-78-5

AI Product Description

*The following content is generated by AI and is for reference only.

Ibandronic acid is a potent third-generation bisphosphonate compound widely utilized in clinical medicine for the management of metabolic bone diseases. Chemically, it belongs to the nitrogen-containing bisphosphonate class, characterized by its unique side chain structure which enhances its affinity for hydroxyapatite crystals found in bone tissue. The molecular formula of Ibandronic acid is C₇H₁₂NO₆P₂, and its standard Chemical Abstracts Service (CAS) registry number is 105468-73-9. This specific chemical identity allows pharmaceutical manufacturers to synthesize high-purity active ingredients essential for both oral tablets and intravenous infusion solutions used globally. The primary therapeutic application of Ibandronic acid is the treatment and prevention of osteoporosis in postmenopausal women. It functions by inhibiting osteoclast-mediated bone resorption. Osteoclasts are the cells responsible for breaking down old bone tissue; by suppressing their activity, Ibandronic acid helps maintain or increase bone mineral density, thereby significantly reducing the risk of vertebral and non-vertebral fractures. Additionally, it is indicated for the treatment of hypercalcemia of malignancy associated with bone metastases in patients with solid tumors, where it helps normalize elevated calcium levels in the blood caused by excessive bone breakdown. Pharmacokinetically, the drug exhibits high selectivity for skeletal tissue due to its strong binding properties. When administered, a significant portion binds to the bone surface, while the remainder is excreted unchanged by the kidneys. Its long half-life within the bone matrix allows for flexible dosing regimens, ranging from daily oral administration to monthly intravenous infusions, improving patient compliance. While generally well-tolerated, common side effects may include gastrointestinal disturbances, musculoskeletal pain, and rare but serious conditions such as osteonecrosis of the jaw or atypical femoral fractures. As a cornerstone therapy in geriatric orthopedics, Ibandronic acid remains a critical tool for preserving skeletal integrity and enhancing the quality of life for millions of patients suffering from severe bone loss disorders worldwide.