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CAS NO:
77029-83-5
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Basic Info
CAS Number
77029-83-5
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Hypocrellin A is a naturally occurring photosensitizing agent belonging to the class of hypericin-like compounds, primarily isolated from the fruiting bodies of *Hypocrella bambusae*, a fungus that infects bamboo. Its molecular formula is C28H26O10, and it carries the CAS registry number 37594-74-8. Structurally, Hypocrellin A features a unique naphthacenedione core with hydroxyl and methoxy substituents, which grants it exceptional photochemical properties. Upon exposure to visible light, this molecule efficiently absorbs photons and transitions to an excited triplet state, facilitating energy transfer to molecular oxygen to generate highly reactive singlet oxygen species.
Due to these potent photodynamic characteristics, Hypocrellin A has garnered significant attention in both biomedical research and clinical applications. It is widely utilized as a photosensitizer in Photodynamic Therapy (PDT), a minimally invasive treatment modality for various cancers and infectious diseases. In PDT protocols, Hypocrellin A selectively accumulates in tumor tissues or pathogenic microorganisms; subsequent irradiation triggers localized oxidative stress, leading to cell death while sparing surrounding healthy tissue. Furthermore, its broad-spectrum antimicrobial activity makes it effective against bacteria, viruses, and fungi, offering potential solutions for treating resistant infections.
Beyond medicine, Hypocrellin A serves as a valuable tool in chemical biology for studying oxidative stress mechanisms and cellular signaling pathways. Researchers also explore its application in environmental remediation, where it aids in the degradation of organic pollutants under light irradiation. Despite its promise, challenges regarding water solubility and systemic toxicity remain active areas of investigation, prompting ongoing development of novel delivery systems and structural derivatives to enhance therapeutic index. As a natural product with a well-defined chemical structure and robust biological activity, Hypocrellin A continues to be a focal point for developing next-generation phototherapeutic agents, bridging traditional mycology with modern precision medicine.
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