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Intermediates&Fine Chemicals

Hydroxyurea

Category:

Intermediates&Fine Chemicals

CAS NO:

127-07-1

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

127-07-1

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Hydroxyurea 127-07-1

AI Product Description

*The following content is generated by AI and is for reference only.

Hydroxyurea, chemically known as carbamide oxide, is a pivotal small-molecule drug primarily utilized in oncology and hematology for its potent antineoplastic and antiviral properties. With the molecular formula CH4N2O2 and a CAS registry number of 127-07-1, this compound functions as a ribonucleotide reductase inhibitor. By selectively blocking the conversion of ribonucleotides to deoxyribonucleotides, it effectively halts DNA synthesis during the S-phase of the cell cycle, thereby suppressing the proliferation of rapidly dividing cells. In clinical practice, hydroxyurea is most notably indicated for the treatment of chronic myeloid leukemia (CML), where it helps control excessive white blood cell counts. It is also a first-line therapy for sickle cell disease (SCD). In SCD management, the drug significantly increases fetal hemoglobin (HbF) levels, which improves red blood cell deformability, reduces hemolysis, and decreases the frequency of painful vaso-occlusive crises and acute chest syndrome. Beyond these primary applications, hydroxyurea has found utility in treating essential thrombocythemia and polycythemia vera, conditions characterized by abnormal platelet or red blood cell production. Furthermore, research continues to explore its potential in combination therapies for various solid tumors and HIV treatment strategies due to its ability to sensitize cells to radiation and other chemotherapy agents. Despite its therapeutic efficacy, the use of hydroxyurea requires careful monitoring due to potential side effects, including myelosuppression, gastrointestinal disturbances, and dermatological reactions. Long-term exposure may rarely lead to secondary malignancies. As an oral agent with a well-established safety profile when managed correctly, hydroxyurea remains a cornerstone medication in managing complex hematologic disorders. Its mechanism of action, targeting the fundamental process of DNA replication, underscores its importance in modern pharmacotherapy. Ongoing studies aim to optimize dosing regimens and expand its application spectrum, ensuring continued relevance in the evolving landscape of cancer and genetic disease treatments. The global demand for this versatile molecule reflects its critical role in improving patient survival rates and quality of life across diverse medical disciplines.