Product Name: 18-Crown-6
CAS number: 17455-13-9
Molecular formula: C12H24O6
Molecular weight: 263.89
Purity (content): 99%
Properties: Almost white solid, easily deliquescent, low melting point, irritating to eyes and skin.
Usage: Used as a metal ion chelating agent; Organic reagents, pharmaceutical intermediates; Used as a chelating reagent and phase transfer catalyst.
Caution: Easy to absorb water, should be stored in a sealed and dry place, and kept in a cool and shady place.
*The following content is generated by AI and is for reference only.
High quality 18-Crown-6 (99% purity) is a macrocyclic polyether renowned for its exceptional ability to selectively complex with alkali metal cations, particularly potassium ions. With the molecular formula C₁₂H₂₄O₆ and a CAS number of 25687-70-5, this compound features a central cavity of approximately 2.6–3.2 Å, perfectly matching the ionic radius of K⁺. This structural complementarity allows 18-crown-6 to form stable, soluble complexes in organic solvents, effectively "solubilizing" inorganic salts that are otherwise insoluble.
The primary application of high-purity 18-crown-6 lies in phase-transfer catalysis. By encapsulating cations such as potassium or cesium, it renders the associated anions highly reactive and nucleophilic within non-polar organic media. This property is indispensable in organic synthesis, facilitating reactions like alkylation, acylation, and oxidation under mild conditions without requiring harsh polar aprotic solvents. Consequently, it significantly accelerates reaction rates and improves yields in pharmaceutical manufacturing and fine chemical production.
Beyond catalysis, 18-crown-6 serves critical roles in analytical chemistry and materials science. It is frequently employed in ion-selective electrodes for detecting specific metal ions and in the separation of isotopes due to its precise binding selectivity. In supramolecular chemistry, it acts as a fundamental building block for constructing host-guest systems, molecular machines, and self-assembled structures. The 99% purity grade ensures minimal interference from impurities, which is vital for sensitive spectroscopic studies and high-stakes industrial processes where consistency is paramount. Furthermore, its stability and well-characterized thermodynamic properties make it a standard reference material in research laboratories worldwide. As a versatile tool bridging inorganic and organic chemistry, 18-crown-6 remains essential for advancing synthetic methodologies and understanding molecular recognition phenomena. Its widespread utility underscores its status as a cornerstone reagent in modern chemical research and development.