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CAS NO:
5843-65-2
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Basic Info
CAS Number
5843-65-2
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Higenamine, chemically known as (R)-N-methyl-2-(3-hydroxyphenyl)ethanamine or N-methyl-dopamine, is a naturally occurring alkaloid primarily isolated from the roots of Aconitum species and Datura plants. Its molecular formula is C9H13NO2, and it holds the CAS Registry Number 60-54-8. Structurally, it functions as a phenethylamine derivative, closely resembling dopamine but with distinct pharmacological properties due to its specific substitution pattern.
Historically, Higenamine has been utilized in traditional Chinese medicine for treating respiratory conditions such as asthma and bronchitis, attributed to its ability to relax smooth muscles in the airways. In modern scientific contexts, it is widely recognized for its potent adrenergic activity. It acts as an agonist at beta-adrenergic receptors and exhibits significant affinity for alpha-adrenergic receptors. This dual mechanism allows it to stimulate lipolysis, making it a popular ingredient in various dietary supplements marketed for weight loss and fat burning. By activating beta-receptors, particularly beta-3 subtypes, it promotes the breakdown of stored triglycerides into free fatty acids, which are then oxidized for energy. Additionally, its positive inotropic effects on cardiac muscle have led to research into its potential applications for heart failure, although clinical use remains limited due to safety concerns regarding cardiovascular stimulation.
Despite its popularity in the supplement industry, the regulatory status of Higenamine varies globally. The World Anti-Doping Agency (WADA) has classified it as a prohibited substance under category S4 (Hormone and Metabolic Modulators), banning its use by athletes during competition. Furthermore, concerns regarding its impact on blood pressure and heart rate have prompted stricter scrutiny in several jurisdictions. While effective for metabolic enhancement in pre-workout formulations, consumers must exercise caution due to potential side effects including tachycardia and hypertension. Ongoing research continues to explore its therapeutic potential while seeking safer analogs that retain efficacy without compromising cardiovascular health. As a result, Higenamine remains a subject of intense debate between its utility in performance enhancement and the necessity for rigorous safety regulation.
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