Category:
Prophylactic Biological Products
CAS NO:
145781-92-6
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Goserelin Acetate
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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
145781-92-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Goserelin Acetate is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH), widely utilized in the clinical management of hormone-dependent conditions. Its molecular formula is C63H92N18O17, and it is identified by the CAS number 84308-53-8. This compound functions as a potent GnRH agonist that initially stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. However, with continuous administration, it downregulates GnRH receptors, leading to a profound suppression of gonadotropin secretion. Consequently, this mechanism drastically reduces the production of sex steroids such as testosterone in men and estradiol in women, creating a medical state similar to surgical castration or menopause without invasive procedures.
The primary therapeutic applications of Goserelin Acetate include the treatment of advanced prostate cancer in males, where lowering testosterone levels helps inhibit tumor growth. In females, it is indicated for managing endometriosis, reducing pain associated with the condition, and shrinking uterine fibroids prior to surgery. Additionally, it plays a crucial role in assisted reproductive technologies by preventing premature ovulation during ovarian stimulation protocols. The drug is typically administered via subcutaneous implantation using specialized depot formulations, which ensure a sustained release of the active ingredient over periods of one month, three months, or six months. This long-acting delivery system significantly improves patient compliance compared to daily injections. Common side effects are generally related to the induced hypoestrogenic or hypogonadal state, including hot flashes, decreased libido, and bone density loss, necessitating careful monitoring during long-term therapy. Overall, Goserelin Acetate remains a cornerstone in modern oncology and gynecology, offering effective hormonal control for various complex medical conditions while maintaining a favorable safety profile when used according to established guidelines.
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