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Ginkgolic Acid C13-0 is a naturally occurring alkylphenol compound belonging to the ginkgolic acid family, primarily isolated from the seed coat of *Ginkgo biloba*. Its molecular formula is C21H42O2, and it carries the CAS Registry Number 84659-75-6. Structurally characterized by a phenolic ring attached to a saturated C13 alkyl chain, this molecule distinguishes itself from other ginkgolic acids by its specific degree of saturation, which influences its biological activity and physicochemical properties.
In scientific research and industrial applications, Ginkgolic Acid C13-0 serves as a critical reagent for studying cell signaling pathways, particularly regarding inflammation and apoptosis. It is widely recognized for its potent inhibitory effects on protein tyrosine phosphatase 1B (PTP1B), making it a valuable tool in diabetes and obesity research. Furthermore, due to its ability to modulate immune responses, it is investigated for potential therapeutic applications in autoimmune disorders and cancer therapy. The compound exhibits significant cytotoxicity against various cancer cell lines while showing relatively low toxicity to normal cells under controlled conditions, suggesting a promising window for drug development.
Beyond biomedical research, Ginkgolic Acid C13-0 finds utility in material science as a precursor for synthesizing bio-based polymers and resins, leveraging its unique alkyl chain structure for surface modification. In the cosmetic industry, derivatives of ginkgolic acids are explored for their antioxidant and anti-inflammatory properties, although the parent compound requires careful handling due to its potential allergenic nature. Strict quality control is essential when sourcing this substance, as natural extracts often contain mixtures of homologs with varying chain lengths. Researchers must ensure high purity to avoid confounding experimental results caused by structural analogues. As a specialized chemical intermediate, Ginkgolic Acid C13-0 bridges the gap between natural product chemistry and targeted pharmacological intervention, offering a versatile platform for advancing both fundamental biological understanding and applied therapeutic strategies in modern medicine.