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*The following content is generated by AI and is for reference only.
Fructus Evodiae Extract, derived from the dried ripe fruit of *Evodia rutaecarpa* (often known as Wu Zhu Yu), is a significant botanical ingredient widely utilized in traditional medicine and modern pharmaceutical research. This extract is rich in bioactive alkaloids, most notably evodiamine, rutaecarpine, wuchuyuine, and dehydroevodiamine, which are responsible for its diverse pharmacological properties. The molecular composition varies depending on the extraction method and plant origin, but the primary active constituents are quinoline alkaloids with complex structures that do not share a single simple molecular formula; rather, they represent a class of compounds where evodiamine (C19H18N2O) and rutaecarpine (C19H14N2O) serve as key markers. While there is no single CAS number for the crude extract itself due to its mixture nature, specific major alkaloids have distinct identifiers, such as CAS 653-97-0 for evodiamine and CAS 481-69-2 for rutaecarpine.
The primary applications of Fructus Evodiae Extract lie in its ability to regulate gastrointestinal function, alleviate pain, and modulate metabolic processes. In Traditional Chinese Medicine (TCM), it has been historically employed to treat vomiting, diarrhea, abdominal pain, and headaches associated with cold patterns. Modern scientific studies have expanded its potential utility, highlighting potent anti-inflammatory, analgesic, and anti-emetic effects. Furthermore, emerging research suggests promising roles in cancer therapy, particularly regarding the inhibition of tumor cell proliferation and induction of apoptosis in various cancer lines. Its ability to improve blood circulation and reduce inflammation makes it valuable in formulations targeting cardiovascular health and metabolic disorders like obesity and diabetes. Additionally, the extract exhibits antimicrobial activity against certain pathogens, supporting its use in natural preservatives or topical treatments. Due to its high concentration of active alkaloids, the extract is standardized in commercial preparations to ensure consistent efficacy and safety profiles. It is commonly found in dietary supplements, herbal capsules, and liquid tinctures designed to support digestive wellness and pain management. As global interest in natural therapeutics grows, Fructus Evodiae Extract remains a critical resource for developing novel drugs and functional foods, bridging ancient wisdom with contemporary biomedical science.