*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Fmoc-Leu-Thr{psi(Me,Me)pro}-OH is a <strong>constrained dipeptide building block</strong> featuring a non-hydrolyzable proline mimic. Synthesized via <strong>solid-phase peptide synthesis</strong> (SPPS) coupling, it stabilizes beta-turn structures. Formula: C26H38N2O7; CAS: 194650-58-3.</p>
<h3>Application</h3>
<ul>
<li><strong>Peptide Drug Development:</strong> Used to enhance metabolic stability in therapeutic candidates.</li>
<li><strong>Structural Biology:</strong> Serves as a tool for probing protein folding mechanisms.</li>
<li><strong>High-Throughput Screening:</strong> Acts as a scaffold for identifying bioactive ligands.</li>
</ul>
<h3>Precautions</h3>
<p>Store at <strong>-20°C</strong> under inert atmosphere. Handle with PPE due to potential sensitization risks. Not for direct clinical administration without formulation.</p>