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<h3>Overview</h3>
<p><strong>Exendin-4</strong> is a 39-amino acid peptide derived from the venom of the Gila monster. It serves as a potent and long-acting agonist for the glucagon-like peptide-1 (GLP-1) receptor, widely utilized in pharmaceutical synthesis for type 2 diabetes management. The molecule features a specific molecular structure with the formula <strong>C<sub>185</sub>H<sub>273</sub>N<sub>47</sub>O<sub>56</sub>S</strong> and CAS number <strong>204656-23-5</strong>. Standard production involves solid-phase peptide synthesis (SPPS) followed by rigorous purification.</p>
<h3>Application</h3>
<ul>
<li>Pharmaceutical manufacturing for GLP-1 receptor agonist drugs like exenatide.</li>
<li>Metabolic research focusing on insulin secretion regulation and glucose homeostasis.</li>
<li>Development of novel therapeutics targeting obesity and metabolic syndrome.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly store at -20°C under inert atmosphere to maintain stability. Handle with appropriate PPE to avoid dermal exposure; potential thyroid C-cell tumors have been observed in rodent studies during preclinical trials.</p>