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<h3>Overview</h3><p>Bivalirudin is a synthetic <strong>direct thrombin inhibitor</strong> with molecular formula C<sub>58</sub>H<sub>79</sub>N<sub>15</sub>O<sub>16</sub>S<sub>2</sub> and CAS 90094-57-0. It is manufactured via solid-phase peptide synthesis to ensure high purity for pharmaceutical use.</p><h3>Application</h3><ul><li><strong>Percutaneous Coronary Intervention (PCI)</strong>: Used as an anticoagulant during catheterization procedures.</li><li><strong>Heparin-Induced Thrombocytopenia (HIT)</strong>: Primary alternative for patients requiring immediate anticoagulation therapy.</li><li><strong>Cardiac Surgery</strong>: Utilized in specific off-pump bypass scenarios to manage clotting risks.</li></ul><h3>Precautions</h3><p>Requires strict monitoring of activated partial thromboplastin time (aPTT). Store lyophilized powder below -20°C; reconstituted solutions must be used immediately. Contraindicated in severe bleeding disorders or active hemorrhage.</p>