Category:
Prophylactic Biological Products
CAS NO:
141732-76-5
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Exenatide Acetate
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
141732-76-5
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Exenatide Acetate is the acetate salt form of Exenatide, a synthetic peptide analog of exendin-4, a 39-amino acid peptide originally isolated from the saliva of the Gila monster (Heloderma suspectum). With the Chemical Abstracts Service (CAS) number 156785-20-1, this compound serves as a critical pharmaceutical intermediate and active ingredient in diabetes management therapies. Its molecular formula is C192H296N52O55S6, reflecting its complex structure derived from the native exendin-4 sequence with specific modifications to enhance metabolic stability and receptor affinity.
The primary therapeutic application of Exenatide Acetate lies in the treatment of type 2 diabetes mellitus. It functions as a glucagon-like peptide-1 (GLP-1) receptor agonist. By mimicking the action of endogenous incretin hormones, it stimulates glucose-dependent insulin secretion from pancreatic beta cells while simultaneously suppressing inappropriate glucagon release from alpha cells. Furthermore, this agent slows gastric emptying and acts on hypothalamic centers to promote satiety, leading to reduced food intake and significant weight loss in patients. Unlike some other antidiabetic agents, Exenatide does not typically cause hypoglycemia when used as monotherapy because its activity is strictly dependent on elevated blood glucose levels.
In the pharmaceutical manufacturing landscape, Exenatide Acetate is widely utilized as a high-purity starting material for the synthesis of injectable formulations such as immediate-release and extended-release depots. The acetate salt form improves the solubility and stability of the peptide during formulation processes, ensuring consistent bioavailability upon administration. Research continues to explore its potential benefits in managing obesity and cardiovascular risk factors associated with metabolic syndrome. As a potent GLP-1 mimic, it has established itself as a cornerstone therapy for patients who require glycemic control alongside weight management, offering a distinct mechanism of action compared to traditional oral hypoglycemics or insulin therapies. Ongoing clinical studies continue to validate its long-term safety profile and efficacy in diverse patient populations worldwide.
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