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Intermediates&Fine Chemicals

Ethyl 2-amino-5-iodobenzoate

Category:

Intermediates&Fine Chemicals

CAS NO:

268568-11-2

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

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Hangzhou Verychem Science And Technology Co.Ltd.

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Basic Info

CAS Number

268568-11-2

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Product Description

pharmaceutical intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

Ethyl 2-amino-5-iodobenzoate is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. With the molecular formula C9H10INO2 and a CAS number of 34476-88-1, this compound features an aromatic benzene ring substituted with an ethyl ester group at position one, an amino group at position two, and a heavy iodine atom at position five. The presence of the iodine substituent makes it particularly valuable as a precursor for cross-coupling reactions, such as Suzuki-Miyaura or Sonogashira couplings, which are essential for constructing biaryl scaffolds found in modern drug candidates. The primary application of Ethyl 2-amino-5-iodobenzoate lies in the development of novel therapeutics, including anti-inflammatory agents, kinase inhibitors, and radiopharmaceuticals. The amino and ester functionalities allow for versatile chemical transformations, enabling researchers to cyclize the molecule into quinazolinones or other nitrogen-containing heterocycles that exhibit potent biological activity. Furthermore, the iodine atom serves as a strategic handle for introducing radioisotopes like Iodine-125, facilitating the creation of diagnostic imaging agents used in nuclear medicine to track metabolic processes within the human body. Its stability under standard laboratory conditions ensures reliable performance during multi-step synthetic routes, making it a preferred building block for medicinal chemists designing structure-activity relationship (SAR) studies. In industrial settings, high-purity batches of this reagent are required to ensure consistent yields and minimize side products during large-scale manufacturing. While the compound is generally stable, it should be stored in a cool, dry place away from light to prevent potential degradation of the carbon-iodine bond. As the demand for targeted therapies and advanced imaging diagnostics continues to grow, the role of halogenated aromatic esters like Ethyl 2-amino-5-iodobenzoate remains critical in accelerating the discovery pipeline for next-generation medicines. Researchers must adhere to strict safety protocols when handling this material due to the irritant nature of its components and the environmental considerations associated with heavy metal waste management.