Category:
Prophylactic Biological Products
CAS NO:
188627-80-7
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Eptifibatide
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
188627-80-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Eptifibatide is a synthetic cyclic heptapeptide belonging to the class of glycoprotein IIb/IIIa inhibitors, widely utilized in clinical cardiology for the management of acute coronary syndromes. Its molecular formula is C38H59N11O9S2, and it carries the CAS Registry Number 146077-57-4. Structurally, Eptifibatide mimics the natural ligand arginine-glycine-aspartic acid (RGD) sequence found in fibrinogen, allowing it to bind reversibly and competitively to the glycoprotein IIb/IIIa receptor on the surface of platelets. By blocking this critical receptor, the drug effectively inhibits platelet aggregation, which is the final common pathway in thrombus formation.
The primary therapeutic application of Eptifibatide involves the prevention of ischemic complications in patients with unstable angina or non-ST-elevation myocardial infarction (NSTEMI). It is frequently administered intravenously as an adjunct therapy alongside aspirin and heparin during percutaneous coronary interventions (PCI), such as angioplasty and stent placement. Clinical studies have demonstrated that Eptifibatide significantly reduces the incidence of death, myocardial infarction, and the need for urgent revascularization procedures when used in these high-risk scenarios. Due to its short half-life of approximately two hours, the drug offers a distinct advantage in procedural settings where rapid onset and quick reversibility are essential; once infusion ceases, platelet function typically recovers within four hours.
While highly effective, the use of Eptifibatide requires careful monitoring due to the risk of bleeding complications, including major hemorrhage and thrombocytopenia. Dosage adjustments are often necessary for patients with renal impairment, as the drug is primarily excreted unchanged by the kidneys. Overall, Eptifibatide represents a cornerstone in modern antithrombotic therapy, providing a potent mechanism to stabilize vulnerable plaques and prevent catastrophic cardiovascular events in the acute setting. Its specific pharmacological profile ensures it remains a vital tool for interventional cardiologists managing complex coronary artery disease cases globally.
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