Product Description
4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-,[1R*,3R*(E),7R*,10S*,11R*,12R*,16S*]-; (-)-Epothilone A; Epo A; Epothilone A
AI Product Description
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Epothilones are potent <strong>microtubule-stabilizing agents</strong> derived from myxobacteria, primarily used as anticancer scaffolds. The core process involves fermentation followed by complex chemical modification to enhance solubility and potency. Key derivatives include Ixabepilone (CAS 214980-92-0) with molecular formula C<sub>26</sub>H<sub>39</sub>NO<sub>5</sub>.</p>
<h3>Application</h3>
<ul>
<li><strong>Oncology:</strong> Treatment of metastatic breast cancer resistant to taxanes.</li>
<li><strong>Drug Development:</strong> Structural template for synthesizing novel tubulin inhibitors.</li>
<li><strong>Research:</strong> Tool compound for studying microtubule dynamics in vitro.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly controlled due to high cytotoxicity; requires PPE during handling. Store at -20°C under inert atmosphere to prevent degradation. Clinical use is limited to specialized oncology protocols under medical supervision.</p>