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CAS NO:
20830-75-5
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Basic Info
CAS Number
20830-75-5
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Digoxin is a cardiac glycoside derived from the leaves of the foxglove plant, Digitalis lanata. Widely recognized in clinical pharmacology, it serves as a critical therapeutic agent for managing specific heart conditions. Its chemical identity is defined by the molecular formula C41H54O14 and the CAS Registry Number 20830-75-5. Structurally, digoxin consists of a steroid nucleus linked to a sugar moiety, which facilitates its interaction with cellular ion pumps.
The primary mechanism of action involves the inhibition of the sodium-potassium ATPase pump located on the cell membranes of cardiac myocytes. By blocking this pump, intracellular sodium levels rise, which indirectly reduces the activity of the sodium-calcium exchanger. Consequently, calcium accumulates within the cells, enhancing myocardial contractility through increased availability of calcium for contraction. This positive inotropic effect allows the heart to pump more blood with each beat, improving cardiac output in patients suffering from heart failure. Additionally, digoxin exerts negative chronotropic effects by increasing vagal tone and slowing conduction through the atrioventricular node. These properties make it particularly valuable for controlling ventricular rate in patients with atrial fibrillation or atrial flutter.
Despite its efficacy, digoxin possesses a narrow therapeutic index, necessitating careful monitoring of serum levels to prevent toxicity. Symptoms of overdose can include nausea, vomiting, visual disturbances such as yellow-green halos, and life-threatening arrhythmias. Due to these risks, dosage adjustments are often required based on renal function, as the drug is primarily excreted unchanged by the kidneys. While newer medications have emerged for heart failure management, digoxin remains an essential component of treatment guidelines, especially for symptom control and rate management in complex cases. Its enduring presence in medical practice underscores its unique ability to improve hemodynamics when used judiciously under strict clinical supervision.
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