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Merck Chemicals (Shanghai) Co., Ltd. is the subsidiary of the globally operating group Merck KGaA, Darmstadt (Germany) and provides Chinese market with high quality life science and chemical products and services
The contact persons for the specific product groups of the Chemicals businesses are listed on the website of Merck Group in China.
*The following content is generated by AI and is for reference only.
Di-ammonium hydrogen citrate is a versatile chemical compound widely utilized across various industrial and pharmaceutical sectors. Primarily serving as a buffering agent, it plays a critical role in maintaining stable pH levels within complex formulations. In the food and beverage industry, this salt acts as an acidity regulator and chelating agent, enhancing product stability by binding metal ions that could otherwise catalyze oxidation or spoilage. It is frequently found in effervescent tablets, sports drinks, and processed foods to ensure consistent texture and shelf life.
In the pharmaceutical domain, di-ammonium hydrogen citrate is essential for formulating antacids and urinary alkalinizers. Its ability to modulate urine pH makes it particularly effective in managing conditions like uric acid stones or cystitis, where altering the urinary environment aids in preventing crystal formation and facilitating dissolution. Furthermore, its solubility profile allows for efficient absorption in liquid medications, making it a preferred choice for pediatric formulations where taste and solubility are paramount.
Regarding safety and handling, while generally recognized as safe (GRAS) when used within regulatory limits, standard laboratory precautions apply. Users should avoid direct contact with eyes and skin, as concentrated solutions may cause mild irritation. Proper ventilation is recommended during powder handling to prevent inhalation of dust particles. Storage requirements dictate keeping the substance in a cool, dry place away from incompatible strong acids or oxidizing agents to prevent decomposition or unwanted reactions. Although non-flammable, it should be stored in sealed containers to maintain hygroscopic integrity and prevent caking.
Manufacturers must adhere to local regulatory guidelines regarding purity grades, ensuring compliance with pharmacopoeial standards such as USP or EP for medical applications. Disposal should follow environmental regulations, avoiding discharge into water systems without prior treatment. Overall, di-ammonium hydrogen citrate remains a fundamental ingredient for optimizing formulation performance, offering reliable buffering capacity and safety when handled with appropriate care and knowledge of its specific application context.