Category:
Prophylactic Biological Products
CAS NO:
16679-58-6
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Desmopressin
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
16679-58-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Desmopressin is a synthetic analog of the natural hormone arginine vasopressin, specifically designed to mimic the antidiuretic and hemostatic properties of the endogenous peptide while minimizing vasoconstrictive effects. Its chemical identity is defined by the molecular formula C46H64N14O12S2, and it is universally recognized by the CAS registry number 35957-18-1. Structurally, desmopressin features a modified amino acid sequence where the L-arginine at position 8 is replaced with D-arginine, and the N-terminal cysteine residue is oxidized to form a disulfide bridge, enhancing its metabolic stability and duration of action compared to native vasopressin.
Clinically, desmopressin serves as a cornerstone therapy for several distinct medical conditions. It is most widely prescribed for the management of central diabetes insipidus, a disorder characterized by excessive urination and thirst due to insufficient production of antidiuretic hormone. By binding to V2 receptors in the renal collecting ducts, it promotes water reabsorption, effectively reducing urine volume and concentrating the urine. Beyond fluid regulation, desmopressin plays a critical role in hemostasis. It is indicated for patients with mild to moderate hemophilia A or von Willebrand disease, where it stimulates the release of factor VIII and von Willebrand factor from endothelial storage sites, thereby improving clotting function during surgical procedures or minor bleeding episodes. Additionally, it is utilized off-label for nocturnal enuresis in children to reduce nighttime bedwetting episodes. The drug is available in various formulations, including intranasal sprays, oral tablets, sublingual melts, and injectable solutions, allowing for flexible dosing strategies tailored to individual patient needs. Due to its potent effect on water retention, careful monitoring of serum sodium levels is essential to prevent hyponatremia, particularly in elderly patients or those with compromised renal function. Overall, desmopressin remains an indispensable pharmaceutical agent in endocrinology and hematology, offering a safe and effective solution for regulating body fluid balance and supporting coagulation pathways.
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