Benzodialammonium (bitter essence) is currently used as an aversive agent, denaturant, food inhibitor and flavoring agent. Bitter extract is included as an inactive ingredient in the USP USP32NF27 edition. However, no use of Chemicalbook as a bitter receptor antagonist or reverse agonist in drug formulation, or in drug preparation for the treatment and/or prevention of obesity, diabetic peripheral neuropathy, and neuropathic pain has been reported.