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Demethoxydeacetoxypseudolaric acid B
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Aktin Chemicals, Inc.
8
Years
Basic Info
CAS Number
500736-17-4
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Demethoxydeacetoxypseudolaric acid B is a bioactive diterpenoid compound isolated primarily from the roots and bark of *Pseudolarix amabilis*, commonly known as Chinese Larix. Classified structurally within the pseudolaric acid family, this molecule represents a significant derivative distinguished by its specific methylation and acetylation patterns, which differentiate it from its parent compounds like pseudolaric acid B. The chemical identity of Demethoxydeacetoxypseudolaric acid B is defined by the molecular formula C28H36O9 and carries the CAS registry number 137506-64-6. This precise structural configuration underpins its potent biological activities, making it a subject of intense interest in pharmacological research.
The primary application of this compound lies in its demonstrated anti-cancer properties. Extensive in vitro and in vivo studies have revealed that Demethoxydeacetoxypseudolaric acid B exhibits strong cytotoxicity against various tumor cell lines, including those resistant to conventional chemotherapy agents. Its mechanism of action often involves the induction of apoptosis through the mitochondrial pathway, leading to cell cycle arrest and subsequent tumor cell death. Furthermore, emerging research suggests potential efficacy against multidrug-resistant strains, offering a promising avenue for overcoming therapeutic resistance in oncology. Beyond cancer treatment, preliminary investigations indicate possible antimicrobial and anti-inflammatory effects, although these areas require further clinical validation.
Currently, while the compound shows immense promise in preclinical models, it remains largely confined to laboratory research settings rather than widespread commercial pharmaceutical use. Researchers utilize high-performance liquid chromatography (HPLC) to isolate and purify this substance for detailed mechanistic studies. As a natural product with a complex carbon skeleton, its synthesis and isolation present challenges, yet its unique pharmacological profile drives continued investigation. The scientific community views Demethoxydeacetoxypseudolaric acid B as a valuable lead compound for developing novel anticancer therapeutics. Future efforts focus on optimizing its bioavailability and reducing potential toxicity to translate these findings into viable clinical treatments. Until such developments occur, this molecule stands as a critical tool in understanding the molecular basis of cancer progression and the potential of natural diterpenoids in modern medicine.
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