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Intermediates&Fine Chemicals

Demeclocycline hydrochloride manufacture 900μg/mg min

Category:

Intermediates&Fine Chemicals

CAS NO:

64-73-3

Standard:

In-house Standards,

Price Range:

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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Basic Info

CAS Number

64-73-3

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Demeclocycline hydrochloride manufacture 900μg/mg min 64-73-3

AI Product Description

*The following content is generated by AI and is for reference only.

Demeclocycline hydrochloride is a semi-synthetic tetracycline antibiotic derived from the bacterium *Streptomyces aureofaciens*. With the molecular formula C21H21ClN2O8 and CAS Registry Number 350-69-2, this compound serves as a potent inhibitor of bacterial protein synthesis. It functions by reversibly binding to the 30S ribosomal subunit, thereby blocking the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This mechanism effectively halts peptide chain elongation, rendering it bacteriostatic against a broad spectrum of Gram-positive and Gram-negative organisms, including various strains of *Staphylococcus*, *Streptococcus*, and *Haemophilus influenzae*. In clinical practice, demeclocycline hydrochloride is primarily utilized for the treatment of infections caused by susceptible pathogens, such as respiratory tract infections, skin conditions, and certain sexually transmitted diseases. However, its most distinctive therapeutic application lies in the management of the Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Unlike other tetracyclines, demeclocycline possesses a unique side effect profile where it induces nephrogenic diabetes insipidus. By interfering with the action of antidiuretic hormone (ADH) on the renal collecting ducts, it promotes water excretion, making it a valuable agent for correcting hyponatremia associated with SIADH when fluid restriction is insufficient or contraindicated. The product specification "900μg/mg min" indicates a high-purity grade, ensuring that each milligram contains at least 900 micrograms of active demeclocycline base equivalent. This potency is crucial for pharmaceutical formulations, guaranteeing consistent dosing and therapeutic efficacy while minimizing the burden of inactive excipients. While effective, its use requires careful monitoring due to potential adverse effects like photosensitivity, gastrointestinal distress, and hepatotoxicity. Consequently, demeclocycline hydrochloride remains a specialized tool in modern pharmacology, bridging the gap between traditional antibacterial therapy and the specific endocrine regulation required for complex fluid balance disorders. Its availability in high-grade forms supports both research applications and critical clinical interventions worldwide.