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Prophylactic Biological Products

Dacomitinib, 1110813-31-4

Category:

Prophylactic Biological Products

CAS NO:

1110813-31-4

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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SICHUAN QINGMU PHARMACEUTICAL CO.,LTD.

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Basic Info

CAS Number

1110813-31-4

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Name		Dacomitinib
Synonyms		PF-00299804-03; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide

Molecular Structure

Molecular Formula		C24H25ClFN5O2
Molecular Weight		469.94
CAS Registry Number		1110813-31-4

pharmaceutical grade

AI Product Description

*The following content is generated by AI and is for reference only.

Dacomitinib, identified by the CAS number 1110813-31-4 and molecular formula C27H29ClFN5O3S, is a potent small-molecule tyrosine kinase inhibitor (TKI) belonging to the class of irreversible epidermal growth factor receptor (EGFR) inhibitors. Originally developed as an investigational drug for oncology, it functions by covalently binding to the ATP-binding site of the EGFR tyrosine kinase domain, thereby blocking downstream signaling pathways that drive cell proliferation and survival in tumor cells. Unlike reversible inhibitors, Dacomitinib forms a permanent bond with the enzyme, offering sustained inhibition even at low concentrations. Clinically, Dacomitinib has garnered significant attention for its application in treating non-small cell lung cancer (NSCLC), particularly in patients harboring specific sensitizing EGFR mutations such as exon 19 deletions or the L858R point mutation. It was approved by regulatory bodies like the US FDA as a first-line treatment option, demonstrating superior progression-free survival compared to older generation TKIs like gefitinib or erlotinib in pivotal clinical trials. Its mechanism involves not only inhibiting wild-type EGFR but also targeting mutant variants that confer resistance to other therapies, making it a valuable tool in precision medicine approaches. Beyond its primary indication, research continues to explore its potential efficacy in other malignancies overexpressing EGFR, including head and neck squamous cell carcinomas and certain types of breast cancer. The compound exhibits high selectivity for EGFR family members while minimizing off-target effects on unrelated kinases, although common side effects such as diarrhea, rash, and stomatitis remain management challenges during therapy. As a critical agent in the evolution of targeted cancer treatments, Dacomitinib represents a significant advancement in extending patient survival and improving quality of life through mechanism-driven pharmacotherapy. Its development underscores the importance of understanding molecular genetics in tailoring therapeutic strategies for complex cancers.