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Other Specialized Reagents

Dabrafenib

Category:

Other Specialized Reagents

CAS NO:

1195765-45-7

Standard:

ChP,USP,BP,EP,JP,In-house Standards,IP,Ph. Int,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jiangsu Magic Biotechnology Co., Ltd

Years

Show Room

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Basic Info

CAS Number

1195765-45-7

Pharmacopoeia

ChP,USP,BP,EP,JP,In-house Standards,IP,Ph. Int

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Packaging & Delivery

Minimum Order Quantity

100g

Delivery Cycle

Product Description

达拉非尼化学性质熔点:214-216oC沸点:653.7±65.0°C(Predicted)密度:1.443储存条件:-20°C溶解度:SolubleinDMSO(upto30mg/mlwithwarming),orinEthanol(upto1mg/mlwithwarming).形态:WhitesChemicalbookolid.酸度系数(pKa):6.62±0.10(Predicted)颜色:Off-white稳定性:Stablefor1yearfromdateofpurchaseassupplied.SolutionsinDMSOorethanolmaybestoredat-20°Cforupto3months.

AI Product Description

*The following content is generated by AI and is for reference only.

Dabrafenib, marketed under the brand name Tafinlar, is a highly selective inhibitor of serine/threonine protein kinases, specifically targeting mutant forms of the BRAF V600E and V600K proteins. Its chemical identity is defined by the molecular formula C21H19ClN4O3S and the CAS registry number 871700-56-6. Structurally, it belongs to the class of small molecule tyrosine kinase inhibitors, designed with high affinity for the ATP-binding pocket of the mutated BRAF enzyme. This specificity allows it to block the aberrant signaling pathways that drive uncontrolled cell proliferation in cancer cells harboring these specific mutations, while sparing normal cells expressing wild-type BRAF. Clinically, Dabrafenib is primarily indicated for the treatment of patients with unresectable or metastatic melanoma who have a confirmed BRAF V600 mutation. It is frequently administered in combination with trametinib, a MEK inhibitor, to enhance therapeutic efficacy and delay the development of drug resistance. The combination therapy has demonstrated significant improvements in progression-free survival and overall response rates compared to single-agent treatments. Furthermore, Dabrafenib is approved for use in pediatric patients with relapsed or refractory solid tumors containing the BRAF V600 mutation. The mechanism of action involves the inhibition of RAF kinase activity, which subsequently suppresses the MAPK/ERK pathway. This suppression leads to the induction of apoptosis and the arrest of the cell cycle in tumor cells. Common side effects associated with its administration include pyrexia, fatigue, headache, nausea, and cutaneous reactions such as rash or photosensitivity. Due to the risk of new primary malignancies and ocular disorders, regular monitoring is essential during therapy. As a targeted therapy agent, Dabrafenib represents a critical advancement in precision oncology, offering personalized treatment options for patients with specific genetic alterations, thereby transforming the management landscape for advanced melanoma and other solid tumors driven by BRAF mutations.