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<h3>Overview</h3>
<p>Cyclosporine is a potent <strong>cyclic undecapeptide immunosuppressant</strong> produced by the fungus <em>Beauveria nivea</em>. Its core synthesis involves fermentation followed by purification. The molecular formula is <strong>C62H111N11O12</strong> with CAS No. <strong>59865-13-3</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Organ Transplantation:</strong> Prevents acute and chronic rejection in kidney, liver, and heart transplants.</li>
<li><strong>Rheumatology:</strong> Treats severe rheumatoid arthritis and psoriasis unresponsive to other therapies.</li>
<li><strong>Ophthalmology:</strong> Manages dry eye disease via topical emulsions.</li>
</ul>
<h3>Precautions</h3>
<p>Requires strict therapeutic drug monitoring due to narrow therapeutic index. Contraindicated in patients with hypersensitivity. Store below 25°C in original packaging to maintain stability.</p>