*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Colistimethate</strong> is a semisynthetic prodrug of polymyxin E, produced via methanesulfonation to enhance water solubility. CAS 1264-72-8; Formula: C<sub>50</sub>H<sub>98</sub>N<sub>14</sub>O<sub>16</sub>S.</p>
<h3>Application</h3>
<ul>
<li>Severe Gram-negative infections in hospital settings.</li>
<li>Neonatal sepsis and meningitis treatment protocols.</li>
<li>Topical formulations for resistant wound infections.</li>
</ul>
<h3>Precautions</h3>
<p>Strict renal function monitoring required due to nephrotoxicity risks. Store in cool, dry conditions below 25°C to maintain stability and prevent degradation.</p>