Category:
Prophylactic Biological Products
CAS NO:
132203-70-4
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Basic Info
CAS Number
132203-70-4
Pharmacopoeia
ChP
Grade
Pharmaceutical Grade
Product Keywords
cilnidipine,,Active Pharmaceutical Ingredients,Other Active Pharmaceutical Ingredients
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
5kg/drum,25kg/drum
Delivery Cycle
with stock
Product Description
A slightly yellowish or yellowish crystalline powder,odourless,tasteless,photolabile.
Solubility:It is very soluble in chloroform,acetone, slightly soluble in methanol,ethanol, almost unsoluble in water, 0.1mol/L HCl, 0.1mol/L NaOH.
Meltintg point:106～109℃
AI Product Description
*The following content is generated by AI and is for reference only.
Cilnidipine is a novel dihydropyridine calcium channel blocker widely utilized in the management of hypertension and chronic kidney disease. Chemically, it possesses the molecular formula C24H30N2O7 and is identified by the CAS Registry Number 105558-63-4. Unlike traditional dihydropyridines that selectively inhibit L-type calcium channels, Cilnidipine exhibits a unique dual mechanism of action. It blocks both L-type and N-type voltage-gated calcium channels. This distinctive pharmacological profile allows it to not only relax vascular smooth muscle to lower systemic blood pressure but also reduce sympathetic nerve activity, thereby decreasing renal sympathetic tone.
The primary clinical application of Cilnidipine is the treatment of essential hypertension. By inhibiting N-type channels in presynaptic sympathetic nerve terminals, it reduces the release of norepinephrine, which contributes to vasodilation and heart rate stability. Furthermore, this drug demonstrates significant renoprotective effects. It effectively lowers intraglomerular pressure and proteinuria, making it particularly valuable for hypertensive patients with diabetic nephropathy or other forms of chronic kidney disease. Clinical studies have shown that Cilnidipine can slow the progression of renal function decline more effectively than some standard antihypertensives alone.
Pharmacokinetically, Cilnidipine is well-absorbed after oral administration and undergoes extensive hepatic metabolism. Its half-life supports once-daily dosing, enhancing patient compliance. Common side effects are generally mild and may include peripheral edema, dizziness, or flushing, though its impact on heart rate is minimal compared to other calcium channel blockers. Due to its ability to target both vascular resistance and neurogenic factors, Cilnidipine represents a sophisticated therapeutic option for complex hypertensive cases requiring comprehensive organ protection. Ongoing research continues to explore its potential benefits in preventing cardiovascular events and preserving renal function in diverse patient populations globally.
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