Cetrorelix acetate supplier Pharmaceutical API Polypeptide made in china 120287-85-6
AI Product Description
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Cetrorelix acetate is a highly potent synthetic gonadotropin-releasing hormone (GnRH) antagonist widely utilized in modern reproductive medicine. Primarily manufactured as a pharmaceutical API in China by leading suppliers specializing in peptide synthesis, this compound plays a critical role in assisted reproductive technologies (ART). Its molecular formula is C62H87N19O14S2·CH3COOH, reflecting its complex structure as a decapeptide derivative modified with an acetic acid salt to enhance solubility and stability. The specific CAS number for Cetrorelix acetate is 153014-16-9, which serves as the unique identifier for regulatory compliance and global sourcing.
The primary clinical application of Cetrorelix acetate is the prevention of premature luteinizing hormone (LH) surges during controlled ovarian stimulation protocols. Unlike traditional GnRH agonists that initially stimulate then suppress LH release, Cetrorelix acts immediately as a competitive antagonist at the pituitary GnRH receptors. This rapid onset allows for flexible administration timing, typically starting on day 5 or 6 of ovarian stimulation, without the risk of early cycle flare-ups. By blocking the LH surge, it preserves oocyte quality and prevents premature ovulation, thereby significantly improving pregnancy rates in IVF and ICSI cycles.
Beyond human reproduction, Cetrorelix is also investigated for treating conditions driven by excessive sex steroid production, such as prostate cancer and endometriosis, though its dominant market presence remains in fertility treatments. As a Chinese-manufactured API, it benefits from rigorous Good Manufacturing Practice (GMP) standards, ensuring high purity levels often exceeding 98% or 99%. Global pharmaceutical companies source this peptide for formulation into injectable solutions like Cetrotide. The availability of high-quality Cetrorelix acetate from China has democratized access to advanced ART medications, supporting millions of patients worldwide seeking successful conception through scientifically managed hormonal cycles.