Category:
Prophylactic Biological Products
CAS NO:
74578-69-1
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Basic Info
CAS Number
74578-69-1
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
Usage : For meningitis, pneumonia, skin and soft tissue infection, peritonitis sensitive bacteria infection, urinary system infection, gonorrhea, biliary infection, surgical trauma, sepsis and genital infection. Has been used as a first-line drug treatment of gonorrhea.
AI Product Description
*The following content is generated by AI and is for reference only.
Ceftriaxone Sodium is a widely utilized third-generation cephalosporin antibiotic, renowned for its broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. Chemically identified by the CAS number 68373-94-0, this compound possesses the molecular formula C18H16N8Na2O7S3. It appears as a white to slightly yellowish crystalline powder and is highly soluble in water, making it ideal for intravenous or intramuscular administration. The sodium salt form ensures rapid dissolution and stability in physiological environments, facilitating effective therapeutic delivery.
Originally developed to overcome resistance mechanisms seen with earlier antibiotics, Ceftriaxone Sodium functions by inhibiting bacterial cell wall synthesis. It binds tightly to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and leading to cell lysis and death. Its unique pharmacokinetic profile allows for once-daily dosing due to a long half-life of approximately 5.8 to 8.7 hours, which enhances patient compliance and simplifies treatment protocols. This drug exhibits excellent tissue penetration, reaching high concentrations in the cerebrospinal fluid, lungs, and bile, which makes it particularly valuable for treating meningitis, pneumonia, and intra-abdominal infections.
Clinically, Ceftriaxone Sodium serves as a first-line therapy for serious infections such as septicemia, gonorrhea, pelvic inflammatory disease, and osteomyelitis. It is also frequently employed in prophylactic settings prior to surgical procedures to prevent post-operative infections. Notably, it remains effective against many beta-lactamase-producing organisms that render other antibiotics ineffective. While generally well-tolerated, potential side effects may include gastrointestinal disturbances, rash, or transient elevations in liver enzymes. Rare but severe hypersensitivity reactions require immediate medical attention. Due to its potency and versatility, Ceftriaxone Sodium stands as a cornerstone medication in modern hospital formularies globally, playing a critical role in combating multidrug-resistant pathogens and improving patient outcomes across diverse clinical scenarios.
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