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CAS NO:
2468-21-5
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Basic Info
CAS Number
2468-21-5
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Catharanthine is a significant indole alkaloid naturally derived from the Madagascar periwinkle plant, scientifically known as *Catharanthus roseus*. With the molecular formula C20H24N2O3 and a CAS Registry Number of 518-73-6, this compound belongs to the family of vinca alkaloids, closely related to other potent anti-cancer agents like vincristine and vinblastine. Structurally characterized by its complex pentacyclic framework containing an oxindole moiety, catharanthine exhibits distinct chemical properties that make it a valuable subject in pharmaceutical research.
The primary application of catharanthine lies within the realm of oncology and medicinal chemistry. While it possesses less direct cytotoxicity compared to its semi-synthetic derivatives, it serves as a crucial precursor in the biosynthesis and total synthesis of more effective chemotherapeutic drugs. Researchers utilize catharanthine to develop novel analogs capable of inhibiting microtubule polymerization, thereby disrupting cell division in rapidly proliferating cancer cells. Furthermore, recent studies have explored its potential neuroprotective effects and its ability to modulate specific neurotransmitter receptors, suggesting possible applications beyond traditional chemotherapy.
In laboratory settings, high-purity catharanthine is essential for structure-activity relationship (SAR) studies. Scientists analyze how minor structural modifications influence biological efficacy, aiming to reduce side effects while maximizing therapeutic outcomes. The compound is also used as a reference standard in analytical chemistry to identify alkaloid profiles in plant extracts via HPLC or mass spectrometry. Despite its clinical significance being primarily historical and foundational, catharanthine remains a cornerstone in the ongoing quest for safer and more targeted cancer treatments. Its isolation and characterization continue to provide insights into plant secondary metabolism and drug design strategies, ensuring its relevance in modern pharmacological science.
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