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Products

Vitamin

Calcipotriol vitamin

Category:

Vitamin

CAS NO:

112965-21-6

Standard:

EP,

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Shanghai Haoyuan Chemexpress Co., Ltd.

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Basic Info

CAS Number

112965-21-6

Pharmacopoeia

Product Keywords

Calcipotriol vitamin,,Active Pharmaceutical Ingredients,Vitamin

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Product Description

【Name】Calcitriol【CAS Registry Number】112965-21-6【Chemical Name】1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)- 【Appearance】White or almost white crystals

AI Product Description

*The following content is generated by AI and is for reference only.

Calcipotriol, often associated with Vitamin D3 derivatives due to its structural similarity, is a synthetic analog of calcitriol (1,25-dihydroxyvitamin D3). Its molecular formula is C27H40O3, and it is uniquely identified by the CAS number 119689-18-4. This pharmaceutical agent functions primarily as a potent regulator of calcium and phosphate metabolism, yet its therapeutic application has been refined specifically for dermatological conditions. Unlike native vitamin D, Calcipotriol exhibits high selectivity for nuclear receptors in skin cells while minimizing systemic effects on calcium homeostasis, making it an ideal candidate for topical treatment. The primary clinical indication for Calcipotriol is the management of mild to moderate plaque psoriasis. It works by modulating keratinocyte proliferation and differentiation. In psoriatic lesions, rapid skin cell turnover leads to thick, scaly plaques; Calcipotriol normalizes this process by slowing down excessive cell growth and promoting orderly maturation. Furthermore, it possesses anti-inflammatory properties that help reduce redness and swelling associated with the disease. By binding to the vitamin D receptor within the nucleus of skin cells, it regulates gene expression involved in cell cycle control and immune response, effectively clearing lesions without the severe side effects often seen with high-potency corticosteroids. Beyond psoriasis, research continues to explore its potential in treating other hyperproliferative skin disorders, such as cutaneous T-cell lymphoma and certain forms of acne, though these remain secondary applications. The drug is typically formulated into ointments, creams, or solutions for once or twice daily application. While generally safe, patients must monitor serum calcium levels during prolonged use, as rare cases of hypercalcemia can occur if large surface areas are treated or if the medication is inadvertently ingested. Calcipotriol represents a significant advancement in non-hormonal dermatology, offering a targeted mechanism that restores skin balance with minimal systemic absorption, thereby improving quality of life for millions suffering from chronic skin conditions.