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Intermediates&Fine Chemicals

Bupivacaine hydrochloride

Category:

Intermediates&Fine Chemicals

CAS NO:

18010-40-7

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

18010-40-7

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Bupivacaine hydrochloride 18010-40-7

AI Product Description

*The following content is generated by AI and is for reference only.

Bupivacaine hydrochloride is a widely utilized long-acting amide-type local anesthetic belonging to the aminoamide class. Chemically, it is the hydrochloride salt of bupivacaine, characterized by the molecular formula C18H29ClN2O and bearing the CAS Registry Number 23647-50-9. This compound functions primarily by reversibly blocking voltage-gated sodium channels on neuronal membranes, thereby inhibiting the initiation and conduction of nerve impulses in a concentration-dependent manner. Its clinical significance lies in its prolonged duration of action compared to shorter-acting agents like lidocaine, making it ideal for procedures requiring sustained anesthesia. In medical practice, Bupivacaine hydrochloride is extensively employed for regional anesthesia techniques, including epidural blocks, spinal anesthesia, peripheral nerve blocks, and local infiltration. It is frequently administered during surgical procedures such as cesarean sections, orthopedic surgeries, and various abdominal operations to provide effective pain relief. Additionally, it serves as a critical component in post-operative pain management protocols, often delivered via continuous infusion catheters or patient-controlled analgesia pumps. The drug is available in various concentrations, typically ranging from 0.25% to 0.75%, allowing clinicians to tailor dosages based on the specific site of administration and the desired depth of anesthesia. Safety considerations are paramount when using this agent due to its potential cardiotoxicity if inadvertently injected intravascularly. Systemic absorption can lead to central nervous system excitation followed by depression, manifesting as dizziness, seizures, or cardiac arrhythmias. Consequently, strict adherence to maximum recommended doses and aspiration prior to injection are essential standard operating procedures. Despite these risks, Bupivacaine hydrochloride remains a cornerstone in modern anesthesiology and pain medicine, offering reliable and extended sensory and motor blockade with a well-established safety profile when used correctly. Its versatility ensures its continued presence in hospital formularies worldwide, supporting both acute procedural needs and chronic pain management strategies.