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CAS NO:
331242-61-6
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Basic Info
CAS Number
331242-61-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
NO
Product Description
- CAS No.：
331242-61-6 - Purity：
≥95% - Molecular formula：
C17H35NO8 - Molecular weight：
381.5 - Uses：
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
AI Product Description
*The following content is generated by AI and is for reference only.
Boc-NH-PEG6-OH is a versatile polyethylene glycol (PEG) derivative widely utilized in medicinal chemistry and bioconjugation research. Its chemical structure comprises a tert-butyloxycarbonyl (Boc) protecting group attached to the amino terminus of a hexa-ethylene glycol chain, which terminates with a hydroxyl group. The molecular formula for this compound is C19H38N2O7, and it is cataloged under CAS number 104513-65-3. This specific architecture offers distinct advantages for synthetic applications due to the orthogonal reactivity of its functional groups.
The Boc group serves as a robust amine protector, allowing chemists to selectively modify the terminal hydroxyl functionality without interfering with the nitrogen center. Conversely, the free hydroxyl group can be easily activated or coupled with carboxylic acids, epoxides, or other electrophiles using standard coupling agents. Once the desired conjugation is achieved, the Boc group can be removed under mild acidic conditions to reveal a primary amine, facilitating further derivatization or peptide synthesis. This dual functionality makes Boc-NH-PEG6-OH an ideal linker for constructing complex macromolecules.
In pharmaceutical development, this reagent is frequently employed to synthesize PEGylated drugs, antibodies, and peptides. The addition of the six-unit PEG spacer significantly enhances the pharmacokinetic profile of therapeutic agents by improving solubility, reducing immunogenicity, and extending circulation half-life in vivo. Furthermore, the precise length of the PEG chain influences the steric hindrance and flexibility of the final conjugate, allowing for fine-tuning of biological activity. Researchers also utilize this compound in the preparation of self-assembling nanoparticles and drug delivery systems where controlled release kinetics are critical. Due to its high purity and stability, Boc-NH-PEG6-OH remains a staple building block in modern organic synthesis and biotechnology laboratories seeking to optimize the efficacy and safety of novel therapeutics through rational molecular design.
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