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CAS NO:
6078-17-7
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Basic Info
CAS Number
6078-17-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Berbamine dihydrochloride is a potent alkaloid derivative widely recognized in pharmacological research for its diverse therapeutic potential. Chemically, it is the dihydrochloride salt form of berbamine, an isoquinoline alkaloid originally isolated from the roots of *Stephania tetrandra*, a traditional Chinese medicinal herb. The molecular formula of berbamine dihydrochloride is C38H42Cl2N2O6, and it carries the CAS Registry Number 1507-96-2. This compound exhibits high solubility in water compared to its free base form, making it more suitable for various pharmaceutical formulations and experimental applications.
In the realm of modern medicine, berbamine dihydrochloride has attracted significant attention due to its multifaceted biological activities. It is primarily investigated for its anti-inflammatory properties, demonstrating efficacy in suppressing pro-inflammatory cytokines and modulating immune responses. Furthermore, extensive studies suggest its cardioprotective effects, including the ability to regulate cardiac ion channels, which may help treat arrhythmias and protect against myocardial ischemia-reperfusion injury. Research also highlights its potential as an anticancer agent, where it induces apoptosis in various tumor cell lines by inhibiting specific signaling pathways such as PI3K/Akt and MAPK.
Beyond oncology and cardiology, this compound shows promise in managing metabolic disorders like diabetes and obesity by improving insulin sensitivity and reducing lipid accumulation. Its mechanism often involves the inhibition of fibroblast proliferation, suggesting utility in treating fibrotic diseases affecting the liver, lungs, or kidneys. As a research tool, berbamine dihydrochloride is frequently utilized in vitro and in vivo models to explore cellular signaling mechanisms and validate drug targets. While clinical trials are ongoing to establish its safety profile and dosage standards for human use, current data underscores its value as a promising lead compound in drug discovery. Scientists continue to refine its synthesis and delivery systems to maximize therapeutic benefits while minimizing potential side effects, positioning berbamine dihydrochloride as a key molecule bridging traditional herbal medicine and contemporary pharmacotherapy.
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