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CAS NO:
478-61-5
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Basic Info
CAS Number
478-61-5
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Berbamine, also known as Tetrahydropalmatine or THP, is a naturally occurring bisbenzylisoquinoline alkaloid primarily extracted from the roots of *Corydalis yanhusuo* and related species in the Berberidaceae family. With the molecular formula C21H26N2O4 and a CAS registry number of 630-97-5, this compound exhibits significant pharmacological potential and has attracted extensive attention in modern medicinal chemistry. Structurally, Berbamine features a complex tetracyclic framework that facilitates interaction with various biological targets, including ion channels and neurotransmitter receptors.
The primary applications of Berbamine center on its cardiovascular and neuroprotective properties. It is widely recognized for its ability to regulate cardiac electrophysiology by blocking specific potassium and calcium channels, making it a candidate for treating arrhythmias and hypertension. Furthermore, Berbamine demonstrates potent anti-inflammatory and analgesic effects, often utilized in traditional Chinese medicine formulations to alleviate pain and reduce swelling. Recent studies have also highlighted its promising role in metabolic disorders; it helps improve insulin sensitivity and may assist in managing type 2 diabetes by modulating glucose metabolism pathways. Additionally, emerging research suggests anticancer activities, where Berbamine inhibits tumor cell proliferation and induces apoptosis in certain cancer lines through mitochondrial pathways.
Beyond therapeutic uses, Berbamine serves as a valuable reference standard in pharmaceutical quality control and analytical research due to its distinct chemical profile. Its safety profile is generally favorable when administered at appropriate doses, though clinical trials continue to refine optimal dosage regimens for various indications. As a bridge between traditional herbal medicine and modern pharmacology, Berbamine represents a vital bioactive molecule with diverse mechanisms of action. Ongoing investigations aim to fully elucidate its molecular targets and optimize its delivery systems for enhanced bioavailability. Consequently, Berbamine stands out as a multifunctional agent with substantial promise for developing novel treatments for cardiovascular diseases, neurological conditions, and metabolic syndromes, solidifying its importance in both academic research and clinical practice globally.
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