Category:
Penicillin
CAS NO:
69-57-8
Standard:
ChP,EP,IP,
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Basic Info
CAS Number
69-57-8
Pharmacopoeia
ChP,EP,IP
Grade
Injection Grade
Is Manufacturer
YES
Samples Provided
YES
Product Description
white crystalline powders; odorless or with a slight specific odor, hygroscopic; they rapidly deteriorate upon exposure to acids, alkalis, or oxidizing agents. They are highly soluble in water and soluble in ethanol.
AI Product Description
*The following content is generated by AI and is for reference only.
Benzylpenicillin Sodium Sterile, commonly known as Penicillin G Sodium, is a vital intravenous antibiotic belonging to the beta-lactam class. Its molecular formula is C₁₆H₁₇N₂NaO₄S, and it carries the CAS registry number 69-53-8. This sterile powder form is specifically designed for reconstitution prior to parenteral administration, ensuring stability and potency in clinical settings. As one of the earliest discovered antibiotics, it remains a cornerstone therapy for infections caused by susceptible Gram-positive bacteria, including Streptococcus species, non-penicillinase-producing Staphylococcus aureus, and certain spirochetes like Treponema pallidum, the causative agent of syphilis. It is also highly effective against Clostridium perfringens and Actinomyces israelii.
The mechanism of action involves the inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby disrupting peptidoglycan cross-linking and leading to cell lysis. Due to its narrow spectrum, it is not effective against organisms producing beta-lactamase enzymes or Gram-negative pathogens. The sodium salt formulation offers superior water solubility compared to procaine or benzathine salts, making it ideal for treating severe systemic infections such as meningitis, endocarditis, septicemia, and pneumonia where rapid bactericidal activity is required.
Clinical usage mandates careful assessment of patient allergy history, as hypersensitivity reactions range from mild rashes to life-threatening anaphylaxis. Dosage must be adjusted based on renal function, as the drug is primarily excreted unchanged by the kidneys. While newer generations of penicillins offer broader spectra, Benzylpenicillin Sodium retains unique efficacy against specific high-mortality infections due to its potent concentration-dependent killing and low cost. Strict aseptic techniques are essential during preparation to maintain sterility. Ultimately, this pharmaceutical agent represents a critical tool in modern medicine for combating serious bacterial diseases, provided it is used judiciously to prevent resistance development and adverse events.
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