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Barlerin (8-O-Acetylshanzhiside methyl ester)
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Aktin Chemicals, Inc.
8
Years
Basic Info
CAS Number
57420-46-9
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Barlerin, chemically identified as 8-O-acetylshanzhiside methyl ester, is a prominent bioactive iridoid glycoside isolated primarily from the roots of *Barleria prionitis* L., a plant widely distributed in tropical and subtropical regions. This compound serves as a significant marker for quality control in traditional herbal medicine preparations. The molecular formula of Barlerin is C₂₆H₃₂O₁₄, with a precise molecular weight of approximately 560.52 g/mol. Its unique chemical structure features an acetylated sugar moiety attached to a core aglycone, distinguishing it from related compounds like shanzhiside methyl ester. The CAS number assigned to this specific substance is 139743-73-8, which facilitates its identification in scientific databases and regulatory documentation.
In terms of pharmacological applications, Barlerin has garnered substantial attention for its diverse biological activities. Extensive research indicates potent anti-inflammatory properties, making it a candidate for treating inflammatory conditions such as arthritis and dermatitis. It functions by modulating key signaling pathways involved in the immune response, thereby reducing the production of pro-inflammatory cytokines. Furthermore, studies suggest that Barlerin exhibits significant antioxidant effects, helping to scavenge free radicals and protect cellular structures from oxidative stress-induced damage. This dual action against inflammation and oxidation positions it as a promising therapeutic agent for chronic diseases associated with these mechanisms.
Beyond direct medicinal use, Barlerin plays a crucial role in the standardization of herbal extracts derived from *Barleria prionitis*. As the plant has been traditionally used to treat fever, infections, and skin disorders, quantifying Barlerin content ensures the efficacy and consistency of commercial herbal products. Additionally, its presence serves as a chemical fingerprint in phytochemical screening, aiding researchers in identifying active constituents within complex plant matrices. While currently utilized mainly in research settings and natural product chemistry, ongoing investigations continue to explore its potential in drug discovery pipelines for novel anti-inflammatory and neuroprotective therapies. Its isolation and characterization represent a vital step in validating the ethnopharmacological claims of *Barleria* species, bridging traditional knowledge with modern scientific validation.
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