Product Description
Bacitracin usp pharmaceutical used by feed addictive in china 1405-87-4
AI Product Description
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Bacitracin USP is a polypeptide antibiotic produced by *Bacillus subtilis* var. trichothecenum, widely recognized for its efficacy against Gram-positive bacteria. In the pharmaceutical sector, it is primarily utilized as a topical agent in ointments and creams to treat skin infections such as impetigo, folliculitis, and minor burns. Its mechanism involves inhibiting cell wall synthesis by binding to lipid carriers that transport peptidoglycan precursors across the bacterial membrane. The United States Pharmacopeia (USP) sets rigorous standards for its purity, potency, and safety, ensuring consistency for medical applications.
In China, Bacitracin has also found significant application as an additive in animal feed, particularly in poultry and swine production. While regulatory frameworks regarding antibiotic use in livestock have tightened globally to combat antimicrobial resistance, Bacitracin remains a permitted growth promoter and therapeutic agent under specific conditions in certain jurisdictions. It helps improve feed conversion ratios, promotes weight gain, and controls intestinal disorders caused by pathogens like *Clostridium perfringens*. The Chinese Ministry of Agriculture regulates its inclusion levels strictly to ensure food safety and minimize residues in meat products.
The chemical identity of Bacitracin is complex due to its nature as a mixture of closely related peptides, predominantly Bacitracin A. Its molecular formula is typically represented as C66H103N17O16S2, though variations exist among its components. The CAS number commonly associated with the active substance, specifically Bacitracin zinc or the base form, varies slightly depending on the salt; however, the base compound is often cited around CAS 1405-87-4. As a zinc salt, it offers improved stability and solubility for both pharmaceutical and agricultural formulations. Despite the rise of alternative antibiotics, Bacitracin remains valuable due to its narrow spectrum of activity, which minimizes disruption to the beneficial gut flora compared to broad-spectrum agents. Continued research focuses on optimizing dosage protocols to balance therapeutic benefits with environmental and public health concerns, ensuring sustainable usage in both human medicine and global agriculture.