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CAS NO:
4318-56-3
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Basic Info
CAS Number
4318-56-3
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
YES
Product Description
ISO chemical factory，stable supplying, competitive price
AI Product Description
*The following content is generated by AI and is for reference only.
Alogliptin, often associated with the INTS-1 designation in specific research contexts or internal cataloging systems, is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor primarily developed for the management of type 2 diabetes mellitus. The chemical entity of Alogliptin benzoate, its common salt form used in pharmaceutical formulations, possesses the molecular formula C18H20N6O2·C7H6O2. Its corresponding CAS number for the free base is 355296-06-1, while the benzoate salt carries the CAS number 853787-89-6. This compound functions by inhibiting the DPP-4 enzyme, which is responsible for the rapid degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preventing this enzymatic breakdown, Alogliptin prolongs the activity of these incretins, thereby enhancing glucose-dependent insulin secretion from pancreatic beta cells and suppressing inappropriate glucagon release from alpha cells.
The therapeutic utility of Alogliptin lies in its ability to improve glycemic control without causing significant weight gain or hypoglycemia when used as monotherapy, distinguishing it from other antidiabetic agents like sulfonylureas. It is widely prescribed either as a single agent or in combination with metformin, thiazolidinediones, or insulin to achieve optimal blood sugar levels in adult patients. Beyond its clinical application, Alogliptin serves as a critical reference standard in pharmacological research and drug development studies. Scientists utilize it to investigate the pathophysiology of diabetes, evaluate new drug delivery systems, and conduct bioequivalence testing. In laboratory settings, high-purity Alogliptin is essential for in vitro assays and animal model studies aimed at understanding metabolic regulation and screening novel DPP-4 inhibitors. Its favorable safety profile and once-daily dosing regimen have made it a cornerstone in modern diabetes care, offering a convenient and effective option for long-term disease management globally.
![4-[[[[6-[(Diethylamino)methyl]-2-naphthalenylmethoxy]carbonyllaminolbenzoic acid](https://eimg.pharmasources.com/image/20241206/xJCFsdgfMrHzqjtgeOixhGQHgVbKi7kAcoEqemzE.jpg)
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