Product Name: Hydrocortisone sodium succinate
Synonyms: a-hydrocort;buccalsone;corlan;cortisol,21-(hydrogensuccinate),monosodiumsalt;cortisol,succinate,sodiumsalt;cortisol21-sodiumsuccinate;cortisolsodiumhemisuccinate;cortisolsodiumsuccinate
CAS: 125-04-2
MF: C25H33O8.Na
MW: 484.52
EINECS: 204-725-5
Mol File: 125-04-2.mol
*The following content is generated by AI and is for reference only.
Hydrocortisone Sodium Succinate (HSS), identified by the CAS number 125-04-2, is a water-soluble sodium salt derivative of hydrocortisone. With a purity often marketed at 99% or higher, this pharmaceutical intermediate and active ingredient serves as a critical glucocorticoid agent in clinical settings. Its molecular formula is C₂₃H₃₁NaO₈, reflecting the addition of a succinic acid moiety to the parent hydrocortisone structure, which significantly enhances its solubility compared to the free alcohol form. This chemical property allows for rapid intravenous or intramuscular administration, making it ideal for emergency situations requiring immediate therapeutic effects.
The primary medical application of Hydrocortisone Sodium Succinate lies in the management of acute inflammatory conditions, severe allergic reactions, and adrenal insufficiency. As a potent anti-inflammatory and immunosuppressive drug, it mimics the action of natural cortisol produced by the adrenal cortex. It is frequently utilized in the treatment of septic shock, anaphylaxis, asthma exacerbations, and various autoimmune disorders where swift reduction of inflammation is vital. The sodium succinate ester acts as a prodrug; once administered, enzymatic hydrolysis in the body releases active hydrocortisone, ensuring effective biological activity while maintaining stability during storage and formulation into injectable solutions.
Beyond human medicine, HSS finds niche applications in veterinary practice for treating similar acute conditions in animals. In industrial contexts, high-purity grades are essential for research and development in pharmacology, serving as a standard reference material for quality control assays and bioavailability studies. The 99% purity specification ensures minimal impurities, reducing the risk of adverse reactions and guaranteeing consistent dosing efficacy. While generally safe under medical supervision, prolonged use requires monitoring for potential side effects such as hyperglycemia, fluid retention, and immune suppression. Overall, Hydrocortisone Sodium Succinate remains a cornerstone medication in emergency care and chronic disease management due to its rapid onset of action and versatile pharmacological profile.
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