Product Description
99% up by HPLC GMP DMF Econazole Nitrate 24169-02-6
AI Product Description
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Econazole Nitrate, identified by CAS No. 24169-02-6, is a widely utilized broad-spectrum antifungal agent belonging to the imidazole class of compounds. With a purity often standardized at 99% for pharmaceutical applications, it is manufactured under strict Good Manufacturing Practice (GMP) guidelines and supported by a valid Drug Master File (DMF), ensuring high quality and regulatory compliance for global markets. The chemical formula of Econazole Nitrate is C₁₈H₁₅Cl₂N₃·HNO₃, reflecting its structure as a nitrate salt of econazole, which enhances its solubility and stability for various dosage forms.
This compound functions primarily by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. By disrupting this biosynthetic pathway, Econazole Nitrate compromises membrane integrity, leading to increased permeability and ultimately cell death in susceptible fungi. Its spectrum of activity covers a diverse range of pathogens, including dermatophytes like Trichophyton and Microsporum, yeasts such as Candida albicans, and dimorphic fungi responsible for systemic infections. Consequently, it is extensively employed in the treatment of cutaneous mycoses, including tinea corporis, tinea cruris, tinea pedis, and candidiasis.
In clinical practice, Econazole Nitrate is formulated into topical preparations such as creams, ointments, powders, and vaginal suppositories due to its excellent skin penetration and low systemic absorption. It is also used in veterinary medicine to treat similar fungal infections in animals. The availability of GMP-certified raw materials with verified DMF status allows pharmaceutical manufacturers to efficiently develop finished products that meet stringent international safety and efficacy standards. Furthermore, its established safety profile and proven efficacy make it a cornerstone therapy in both human and animal healthcare sectors for managing superficial fungal diseases. As research continues, Econazole Nitrate remains a critical active pharmaceutical ingredient (API) in the global fight against fungal resistance and infection control.
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