Product Description
99% up GMP DMF Acyclovir 59277-89-3
AI Product Description
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Acyclovir, identified by the CAS number 59277-89-3, is a widely utilized antiviral medication belonging to the class of synthetic nucleoside analogues. Its molecular formula is C8H11N5O3, with a molecular weight of approximately 225.21 g/mol. This compound is primarily synthesized and supplied in high-purity forms, often adhering to Good Manufacturing Practice (GMP) standards, such as those indicated by the "99% up" specification mentioned in industry catalogs. The substance typically exists as a white to off-white crystalline powder, characterized by its stability under standard storage conditions when kept dry and protected from light.
The primary therapeutic application of Acyclovir lies in the treatment of infections caused by herpes simplex virus types 1 and 2, as well as varicella-zoster virus. It functions through a mechanism of selective inhibition of viral DNA polymerase. Upon entering infected cells, the drug is phosphorylated by viral thymidine kinase into acyclovir monophosphate, which is subsequently converted to di- and triphosphate forms by cellular enzymes. The resulting acyclovir triphosphate competitively inhibits viral DNA synthesis and incorporates into the growing viral DNA chain, causing premature termination. Consequently, it effectively manages clinical manifestations such as genital herpes, cold sores, shingles, and chickenpox.
In the pharmaceutical supply chain, Acyclovir serves as a critical Active Pharmaceutical Ingredient (API). Manufacturers producing bulk drugs require high-quality raw materials with purity levels exceeding 99% to ensure patient safety and efficacy. These materials are frequently accompanied by Drug Master Files (DMF), which provide detailed information on the manufacturing process, quality control, and stability data to regulatory bodies like the FDA or EMA. The availability of GMP-certified Acyclovir ensures that downstream formulations, including tablets, capsules, ointments, and intravenous solutions, meet rigorous global health standards. Beyond human medicine, research continues to explore its potential in broader antiviral contexts, though its established role remains central to managing herpesvirus-related diseases worldwide.
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