Beijing Hope Pharmaceutical Co., Ltd. is a high-tech pharmaceutical company based in China and facing the world. The main business is R&D, production and sales of APIs and APIs, import and export trade, R&D of new pharmaceutical preparations and new drug registration. We have an R&D center in Beijing, a pharmaceutical intermediate production base in Hebei and Zhejiang, and a GMP-certified API production base in Shandong.
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8-Hydroxyquinoline, also known as oxine, is a versatile organic compound with the molecular formula C9H7NO and the CAS Registry Number 148-24-3. This heterocyclic substance appears as a pale yellow to white crystalline powder or needle-like crystals. It is characterized by its ability to act as both a weak acid and a weak base, owing to the presence of both hydroxyl and nitrogen groups within its quinoline ring structure. A defining feature of 8-hydroxyquinoline is its exceptional chelating capability; it forms stable, water-insoluble complexes with a wide range of metal ions, including copper, zinc, iron, and aluminum. This property makes it a fundamental reagent in analytical chemistry for the gravimetric determination and separation of metals.
In industrial applications, 8-hydroxyquinoline serves as a crucial intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is widely utilized as a fungicide and bacteriostatic agent in agriculture and horticulture to protect crops from fungal infections and bacterial rot. Its antimicrobial properties are also leveraged in the formulation of mouthwashes and topical antiseptics to control oral bacteria and prevent gum disease. Furthermore, the compound plays a significant role in materials science, particularly in the development of luminescent materials and sensors for detecting specific metal ions due to its fluorescence properties when complexed with transition metals.
The compound exhibits moderate solubility in organic solvents like ethanol and ether but has limited solubility in cold water, which aids in purification processes. While effective, handling requires care as it can be toxic if ingested or absorbed through the skin, necessitating appropriate safety protocols during laboratory and industrial use. Its unique chemical profile ensures its continued relevance across diverse sectors, from environmental monitoring to advanced material engineering. As a multifunctional ligand, 8-hydroxyquinoline remains indispensable for researchers and manufacturers seeking efficient solutions for metal extraction, biological preservation, and functional material synthesis.