6-氟吲哚化学性质熔点:72-76°C(lit.)沸点:230°C(roughestimate)密度:1.1203(estimate)储存条件:Keepindarkplace,Sealedindry,RoomTemperature形态:CrystallinePowder酸度系数Chemicalbook(pKa):16.40±0.30(Predicted)颜色:Beige-brown水溶解性:Insoluble敏感性:LightSensitiveBRN:112192InChI:InChI=1S/C8H6FN/c9-7-2-1-6-3-4-10-8(6)5-7/p-5,10H
*The following content is generated by AI and is for reference only.
6-Fluoroindole is a specialized heterocyclic organic compound widely utilized in the fields of medicinal chemistry and agrochemical research. With the molecular formula C8H6FN and a molecular weight of approximately 147.14 g/mol, this compound features an indole core substituted with a fluorine atom at the sixth position. Its standard CAS registry number is 23956-66-1, which serves as its unique identifier for chemical databases and regulatory compliance. The introduction of the fluorine substituent significantly alters the electronic properties and lipophilicity of the parent indole structure, often enhancing metabolic stability and membrane permeability in biological systems. Consequently, 6-fluoroindole has become a critical building block for the synthesis of complex pharmaceutical agents, including potential anti-inflammatory drugs, analgesics, and neuroactive compounds. Researchers frequently employ it as a key intermediate to construct advanced indole-based scaffolds found in various bioactive molecules. Beyond pharmaceutical applications, this compound also finds utility in the development of novel agrochemicals, where it contributes to the creation of more effective pesticides and herbicides with improved environmental profiles. The high reactivity of the indole nitrogen allows for diverse functionalization strategies, enabling chemists to tailor specific derivatives for targeted therapeutic effects. Furthermore, the presence of the fluorine atom can influence the binding affinity of the molecule to specific protein receptors, making it invaluable in structure-activity relationship (SAR) studies. Due to its specific physical properties, such as being a solid at room temperature with defined melting points, it requires careful handling and storage under inert atmospheres to prevent degradation. As the demand for precision medicine grows, 6-fluoroindole remains a staple reagent in laboratory settings, facilitating the rapid prototyping of new drug candidates. Its availability from major chemical suppliers ensures that researchers globally can access this essential precursor for advancing scientific discovery in organic synthesis and drug development.
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