Product Description
5,7-二氟苯并二氢吡喃-4-酮化学性质沸点:283℃密度:1.392闪点:121℃储存条件:Sealedindry,RoomTemperatureInChI:InChI=1S/C9H6F2O2/c10-5-3-6Chemicalbook(11)9-7(12)1-2-13-8(9)4-5/h3-4H,1-2H2InChIKey:OJVRCPGUGZXUAP-UHFFFAOYSA-NSMILES:C1OC2=CC(F)=CC(F)=C2C(=O)C1
AI Product Description
*The following content is generated by AI and is for reference only.
5,7-Difluorochroman-4-one is a specialized heterocyclic compound belonging to the chromanone family, widely utilized in medicinal chemistry and pharmaceutical research. With the molecular formula C9H6F2O2 and a molecular weight of approximately 182.14 g/mol, this substance features a fused benzene ring substituted with two fluorine atoms at the 5 and 7 positions, coupled with a carbonyl group at the 4-position of the dihydropyran ring. The specific introduction of fluorine atoms significantly enhances the metabolic stability, lipophilicity, and binding affinity of the molecule compared to its non-fluorinated analogs, making it an invaluable scaffold for drug discovery programs.
Although a specific CAS number is not universally standardized for every minor derivative without precise stereochemical definition or supplier variation, it is generally cataloged under distinct identifiers by major chemical suppliers for inventory tracking. Its primary application lies in the synthesis of bioactive molecules targeting various disease states, including oncology, cardiovascular disorders, and neurological conditions. Researchers frequently employ 5,7-difluorochroman-4-one as a key intermediate in multi-step organic synthesis to construct complex pharmacophores. The electron-withdrawing nature of the fluorine substituents modulates the electronic properties of the aromatic system, facilitating nucleophilic attacks and other critical coupling reactions essential for building diverse libraries of potential therapeutics.
In laboratory settings, this compound serves as a crucial tool for structure-activity relationship (SAR) studies, allowing scientists to optimize lead compounds for improved potency and selectivity. Its structural rigidity also aids in reducing entropic penalties during receptor binding. While not typically available as a bulk commercial product for general industrial use, it is readily accessible through specialized chemical vendors for academic and industrial R&D purposes. Strict adherence to safety protocols is recommended during handling, as with most synthetic organic intermediates, due to potential irritant properties. Overall, 5,7-difluorochroman-4-one represents a sophisticated building block that bridges fundamental organic chemistry with advanced therapeutic development, driving innovation in the creation of next-generation medicines with enhanced pharmacokinetic profiles.
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