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<h3>Overview</h3>
<p><strong>5-Methoxyindole-2-carboxylic acid</strong> (CAS: 1006-48-6) is a specialized heterocyclic intermediate with molecular formula C11H9NO3. It is primarily synthesized via Vilsmeier-Haack formylation followed by oxidation of 5-methoxyindole, serving as a key scaffold for pharmaceutical development.</p>
<h3>Application</h3>
<ul>
<li>Synthetic building block for indomethacin derivatives in anti-inflammatory drug manufacturing.</li>
<li>Precursor for developing novel kinase inhibitors and anticancer agents.</li>
<li>Intermediate in the production of agrochemical fungicides targeting fungal cell walls.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at temperatures below -20°C to prevent hydrolysis. Personnel must utilize appropriate PPE including nitrile gloves and respirators due to potential respiratory irritation and skin sensitization during handling.</p>