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5-Chlorothiophene-2-carbonyl chloride

Category:

Other Intermediates

CAS NO:

42518-98-9

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Xinnuo Pharmaceutical Co., Ltd

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Basic Info

CAS Number

42518-98-9

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Samples Provided

Product Description

Cigna Qingdao is mainly engaged in the intermediates of febuxostatin, ceflothrin, eprazole, flubiprofen, phenalidone, tovaptan, rivaroxaban and Avanafil, terbinafine intermediates, thioacetamide and thiophene and their derivatives.

AI Product Description

*The following content is generated by AI and is for reference only.

5-Chlorothiophene-2-carbonyl chloride is a highly reactive acyl chloride derivative widely utilized in organic synthesis and medicinal chemistry. With the molecular formula C₅H₂Cl₂OS and CAS Registry Number 10437-88-6, this compound features a thiophene ring substituted with a chlorine atom at the fifth position and an acid chloride group at the second position. The presence of the electron-withdrawing chloro substituent significantly enhances the electrophilicity of the carbonyl carbon, making it an excellent reagent for nucleophilic acyl substitution reactions. This chemical serves as a crucial building block for constructing complex heterocyclic systems and bioactive molecules. Its primary application lies in the synthesis of amides, esters, and thioesters through reaction with amines, alcohols, or thiols under mild conditions. In pharmaceutical research, 5-chlorothiophene-2-carbonyl chloride is frequently employed to introduce thiophene motifs into drug candidates, which are known for their metabolic stability and potential therapeutic efficacy against various diseases, including inflammation and cancer. Furthermore, it acts as a key intermediate in the production of agrochemicals, such as fungicides and herbicides, where the thiophene scaffold plays a vital role in biological activity. Due to its moisture sensitivity, handling requires strict adherence to safety protocols. The compound reacts vigorously with water to release hydrogen chloride gas, necessitating storage in airtight containers under inert atmospheres like nitrogen or argon. It should be kept in a cool, dry place away from incompatible substances such as strong bases and oxidizing agents. While effective in laboratory-scale syntheses, industrial applications demand specialized equipment to manage the corrosive byproducts generated during processing. Researchers appreciate its versatility in enabling the rapid assembly of diverse molecular architectures, facilitating high-yield transformations essential for advancing drug discovery pipelines and material science innovations. Overall, 5-chlorothiophene-2-carbonyl chloride remains an indispensable tool for chemists seeking to functionalize thiophene-based structures efficiently.