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5-Chloro-2-thiophenecarboxylic acid

Category:

Other Intermediates

CAS NO:

24065-33-6

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Xinnuo Pharmaceutical Co., Ltd

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Basic Info

CAS Number

24065-33-6

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Samples Provided

Product Description

Cigna Qingdao is mainly engaged in the intermediates of febuxostatin, ceflothrin, eprazole, flubiprofen, phenalidone, tovaptan, rivaroxaban and Avanafil, terbinafine intermediates, thioacetamide and thiophene and their derivatives.

AI Product Description

*The following content is generated by AI and is for reference only.

5-Chloro-2-thiophenecarboxylic acid is a specialized heterocyclic organic compound widely utilized in the fields of medicinal chemistry and agrochemical synthesis. With the molecular formula C₅H₃ClO₂S and a CAS Registry Number of 38607-96-4, this substance features a thiophene ring substituted with both a chlorine atom at the fifth position and a carboxylic acid group at the second position. The presence of the sulfur-containing five-membered ring imparts unique electronic and steric properties, making it an invaluable building block for constructing complex pharmaceutical agents and bioactive molecules. In the pharmaceutical industry, this intermediate plays a pivotal role in the development of novel drugs targeting various therapeutic areas, including anti-inflammatory, antimicrobial, and anticancer applications. Chemists frequently employ it as a precursor to synthesize amides, esters, or heterocyclic derivatives that exhibit enhanced biological activity compared to their parent structures. The carboxylic acid functionality allows for versatile coupling reactions, while the chloro substituent offers a strategic handle for further cross-coupling transformations, such as Suzuki or Heck reactions, facilitating the introduction of diverse aromatic moieties. Beyond medicine, 5-chloro-2-thiophenecarboxylic acid finds significant application in the agrochemical sector. It serves as a key component in the manufacturing of herbicides and fungicides designed to protect crops from pests and diseases. The specific substitution pattern on the thiophene ring often correlates with high efficacy and selectivity against target organisms, ensuring minimal impact on non-target species. Furthermore, researchers utilize this compound in material science to explore organic semiconductors and conductive polymers, leveraging the electron-deficient nature of the thiophene core modified by the electronegative chlorine atom. Handling this chemical requires standard laboratory safety precautions due to its potential irritant properties. It is typically supplied as a white to off-white crystalline powder, stable under normal storage conditions but sensitive to strong bases which may cause decarboxylation. As demand grows for more efficient synthetic routes to advanced functional materials, the importance of reliable sources for high-purity 5-chloro-2-thiophenecarboxylic acid continues to rise within the global chemical supply chain, supporting innovation across multiple scientific disciplines.