Huateng Pharmaceutical, a global supplier of pharmaceutical intermediates, offers Ribociclib & Palbociclib intermediate 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine (CAS No.: 733039-20-8) for your requirements of R&D, evaluation, pilots and commercial along with a supportive technical package required for evaluation.
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5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine is a specialized heterocyclic organic compound widely utilized in medicinal chemistry and pharmaceutical research as a versatile intermediate for synthesizing complex bioactive molecules. With the chemical formula C9H10BrClN3, this pyrimidine derivative features a unique substitution pattern comprising a bromine atom at the 5-position, a chlorine atom at the 2-position, and a cyclopentylamino group attached to the 4-position of the pyrimidine ring. This specific structural arrangement provides an ideal scaffold for nucleophilic aromatic substitution reactions, allowing chemists to selectively replace the halogen atoms with various functional groups to generate diverse analogs.
The primary application of this compound lies in the development of kinase inhibitors and other targeted therapeutics. The presence of multiple leaving groups (bromine and chlorine) enables stepwise modification, facilitating the construction of libraries of compounds for structure-activity relationship (SAR) studies. Researchers frequently employ this molecule as a key building block to create novel derivatives with potential anti-cancer, anti-inflammatory, or antimicrobial properties. Its stability under standard laboratory conditions makes it suitable for multi-step synthesis protocols common in drug discovery pipelines.
In academic and industrial settings, this reagent serves as a critical tool for exploring the pharmacological potential of substituted pyrimidines. By varying the substituents introduced through cross-coupling or substitution reactions, scientists can fine-tune the electronic and steric properties of the final drug candidates. Furthermore, the cyclopentyl moiety contributes to metabolic stability and membrane permeability, often enhancing the biological profile of the resulting compounds. While not typically used as a standalone therapeutic agent, its role as a synthetic precursor is indispensable in modern medicinal chemistry. The compound is generally supplied as a high-purity solid, requiring appropriate handling procedures due to the presence of reactive halogens. As the demand for novel small-molecule drugs grows, intermediates like 5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine remain essential components in the arsenal of chemical biologists aiming to address unmet medical needs through rational drug design.