The total synthesis of Taxol has been successful by three laboratories in the United States through different routes, but due to the complexity and high cost of the synthesis steps, it has no industrial application. Later, it was found that 102 dechemicalbook acetylbacatine III (102DAB) extracted from yew leaves could be used for semi-synthesis, and paclitaxel could be obtained by introducing chiral paclitaxel side chain f into the 102DAB molecule. Therefore, paclitaxel side chain as a pharmaceutical intermediate is mainly used in the synthesis and preparation process of APIs.